About the evidence
Ask what the human evidence for this specific peptide actually looks like: are there randomized controlled trials in people, or mostly animal and lab data? How large were the studies, and what exactly did they measure? A trustworthy answer will distinguish between 'shown in people' and 'plausible based on mechanism.'
It's also fair to ask what the evidence does not support, and where the honest uncertainty is. For peptides with limited human data, a good provider will tell you that plainly rather than overselling.
About safety and fit
Ask whether your particular health history or current medications change the picture — including supplements, which people often forget to mention. Ask what side effects to watch for, which ones are common and benign versus rare and serious, and what would make the provider pause or stop therapy.
Ask whether labs are involved, what they'll be checking, and how often. And ask what the plan is if it isn't working: how long before you'd reassess, and what 'not working' would even look like.
About regulatory status and sourcing
Ask whether the peptide is an FDA-approved active or a compounded preparation, and what that distinction means for you. Compounded medications are not FDA-approved or reviewed by the FDA for safety or effectiveness, and you deserve to know which bucket you're in.
It's reasonable to ask where the medication is sourced — whether it's an approved product or compounded by a licensed pharmacy — and how it's overseen. Clear answers are a good sign; evasiveness is not.