Compounded medications are not FDA-approved. Prescriptions are issued only after an online consultation with a licensed provider.
Pick your starting point.
Brand-name GLP-1s like Wegovy and Zepbound are prescribed by a physician licensed in your state and shipped directly by the manufacturer through LillyDirect and NovoCare, at manufacturer pricing.
What actually
happens, week by week.
When we turn you away.
Free 4-minute intake.
A typical 12-week program starts here. You complete a structured intake about medical history, current medications, and weight history. Your physician reviews your case (typically same business day) and either approves a starting dose, asks for a clarifying message, or refers you to a different pathway.
Starting dose. Days 1–4 set the baseline.
Foundayo titration begins at the low starting dose. Most members tolerate the first week without significant nausea. Clyne Concierge can answer questions about what to expect; your care team logs symptoms and adjusts only if needed.
Appetite signal changes.
STEP 1 (NEJM 2021) reported mean weight loss of 14.9% at 68 weeks on semaglutide 2.4 mg, with the largest acceleration starting in the first weeks. By week 4 the trial cohort had begun the steady reduction phase. Dose adjustments (up or down) are physician-driven, not algorithmic.
Lean-mass conversation.
Per the lean-mass meta-analysis (Obesity 2023), 25–39% of total GLP-1 weight loss is lean mass without intervention. Resistance training plus 1.4 g/kg protein attenuates that by ~50% per the same review. Your care team discusses protein targets and any movement plan you'd like to add.
Plateau is expected.
Weight loss on GLP-1s is rarely linear. Plateaus of 1–2 weeks at any stage are normal. Your physician reviews your trend and either holds the dose or adjusts based on tolerability.
First program block ends.
SURMOUNT-1 (NEJM 2022) reported 15.0% / 19.5% / 20.9% mean weight loss across tirzepatide doses at 72 weeks. STEP 1 reported 14.9% on semaglutide 2.4 mg at 68 weeks. Where any individual member lands is reviewed with their physician; a maintenance plan or dose adjustment is set at this point.
Off-ramp planned from day 1.
Per STEP 4 (JAMA 2021), members who discontinued semaglutide regained ~2/3 of lost weight within 12 months. Continued therapy maintained loss. Obesity is a chronic condition; your physician designs a maintenance dose with that in mind.
Three molecules. One subscription.
One subscription. Cancel any time. Follow-ups and Clyne Concierge included.
- Daily oral orforglipron, physician-titrated
- Clyne Concierge available anytime
- Physician review monthly
- Care-team messaging unlimited
- Weekly semaglutide injection, physician-titrated
- Fulfilled directly via NovoCare
- Cold-chain shipping included
- Same Concierge + physician care
- Weekly tirzepatide injection, physician-titrated
- Better lean preservation in trials
- Endo + obesity medicine review
- Fulfilled directly via LillyDirect
Every weight-loss treatment. Pick a path.

Prescriptions are issued only after an online consultation with a licensed provider. Compounded medications are not FDA-approved.
Ready to start losing weight?
The online visit is free. Most members finish in under 10 minutes. From $149/mo.
The phase-3 tape.
The trial data. Cited.
The questions every member asks. Answered straight.
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