NAD+
NAD+ is a coenzyme involved in cellular energy production. Prescription-only, physician-reviewed; cellular-energy structure/function framing.
- Routeinjection or IV
- Baseline labsNot typically required
- EvidenceLimited human data
- AvailabilityAvailable with Rx
How it works
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell and absolutely central to metabolism — it's one of the main electron carriers in the reactions that convert food into ATP, the cell's energy currency. It also serves as a substrate for enzymes involved in DNA repair and cellular signaling, including the sirtuins that feature heavily in aging research.
NAD+ levels are observed to decline with age, and that observation is what drives much of the interest in replenishing it. The honest caveat is large here: showing that a molecule is biochemically essential, and that its levels fall over time, is not the same as showing that supplementing it produces specific health benefits in people. We frame NAD+ in that structure/function context and don't promise outcomes.
What it's been studied for
- Cellular energy metabolism and mitochondrial function
- Aging-biology research contexts (including sirtuin and DNA-repair pathways)
- Markers of metabolic function
“Studied for” describes what research has examined — not a promise of any outcome for you.
What the evidence says
Human data for this peptide is limited. A licensed provider can discuss what the current evidence does and does not support for you.
What to expect at Clyne
NAD+ is given by injection or IV under provider direction. A provider reviews your intake to decide whether it's appropriate, and IV administration is done in an appropriate clinical setting rather than at home.
Your provider explains what a session involves and what to watch for. As a compounded preparation, it is not FDA-approved.
Safety & considerations
Rapid IV administration is well known to cause transient discomfort — chest tightness, flushing, nausea, or a racing sensation — which typically eases when the infusion is slowed. That's a major reason NAD+ is provider-directed rather than self-administered.
Your provider screens your history and can decline if it isn't right for you. Be candid about cardiovascular symptoms and any prior reactions to infusions.
Regulatory status
This peptide may be compounded by a licensed pharmacy under a patient-specific prescription. Compounded medications are not FDA-approved. A regulatory category that permits compounding is not the same as FDA approval.
Common questions
What does NAD+ actually do in the body?
It's a coenzyme that shuttles electrons in energy metabolism and acts as a substrate for repair and signaling enzymes. It's biochemically essential — but essential isn't the same as 'supplementing it will do X for you,' so we keep to structure/function language.
Why does IV NAD+ feel uncomfortable?
Fast administration commonly causes transient sensations like flushing or chest tightness. Slowing the infusion usually helps, which is one reason it's done under clinical supervision.
